Interleukin-1α, -6, and -8 decrease Cdc42 activity resulting in loss of articular chondrocyte phenotype
نویسندگان
چکیده
منابع مشابه
The Value of Interleukin-8 and Interleukin-6 in Cervical Secretions as Predictors of Preterm Delivery
Background and Objective: Preterm birth occurs in 8% to 11% of all pregnancies and is responsible for 75% to 80% of all neonatal deaths. Cytokines may be involved in the etiology of preterm birth through their stimulation of prostaglandin synthesis. Cytokines may be released intocervicovaginal fluid during the breakdown of the chorio-decidual adhesion or from an inflammatory reactio...
متن کاملSmall G-protein activation in articular chondrocytes by interleukin-6, interleukin-8, and osteogenic protein-1
The studies outlined in this honor’s thesis were designed to better understand the mechanisms at both the cellular and molecular levels associated with the onset of osteoarthritis. The horse was used as a model organism, and the experiments were performed on normal equine chondrocytes cultured in vitro. Interleukin-6 (IL-6) and interleukin-8 (IL-8) are known to have catabolic effects on the car...
متن کاملP-77: Follicular Fluid Concentrations of Interleukin-6, Interleukin-8, TNF-α and Interleukin 10 in Polycystic Ovarian Syndrome Women
a:4:{s:10:"Background";s:504:"While the etiology of PCOS has continued to remain a mystery, there can be found some evidence in support of the presence of chronic low-grade inflammation in women with this syndrome. One of the most significant manifestations of chronic inflammation is Pro-inflammatory cytokines. Therefore, the aim of this prospective study was to investigate the pattern of proinfla...
متن کاملRegulation of articular chondrocyte phenotype by bone morphogenetic protein 7, interleukin 1, and cellular context is dependent on the cytoskeleton.
Bone morphogenetic proteins (BMPs) induce cartilage differentiation and morphogenesis. There are profound changes in the cytoskeletal architecture during the morphogenesis of cartilage. To investigate the possibility that morphogenetic signals such as BMPs may regulate chondrocyte phenotype by modulation of cytoskeletal protein expression, we determined whether the expression and distribution o...
متن کاملthe role of interleukin-6 and interleukin-8 gene polymorphisms in non-alcoholic steatohepatitis
conclusions il6 and il8 gene polymorphisms have no role in nash pathogenesis and liver fibrosis process, but presence of the a/a genotype in the il8 gene is associated with disease progression. patients and methods consecutive patients with biopsy proven nash and age- and gender-matched healthy individuals with normal liver function tests and normal ultrasonography were enrolled in the study. h...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2011
ISSN: 0736-0266
DOI: 10.1002/jor.21515